Human RecQL4 as a Novel Molecular Target for Cancer Therapy

Human RecQ helicases play diverse roles in the maintenance of genomic stability. Inactivating mutations 3 5 human are responsible for pathogenesis Werner syndrome (WS), Bloom (BS), Rothmund-Thomson (RTS), RAPADILINO, and Baller-Gerold (BGS). WS, BS, RTS patients at increased risk developing many age-associated diseases including cancer. Mutations RecQL1 RecQL5 have not yet been associated with any so far. In terms disease outcome, RecQL4 deserves special attention because result autosomal recessive syndromes (RTS type II, BGS). RecQL4, like other helicases, has demonstrated to a crucial role stability through participation DNA metabolic activities. Increased incidence osteosarcoma RecQL4-mutated elevated expression sporadic cancers suggest that loss or gain is linked cancer susceptibility. this review, current future perspectives discussed on potential use as novel therapeutic target.